Common Chemical Hazards

It is the responsibility of the investigator to notify research personnel and ACS staff of any hazards and special operating procedures required to handle animals exposed to chemical hazards.

UF EH&S Chemical Hygiene Plan

ACS Chemical Hazard SOP (Template available soon)

UF IACUC Toxic Chemical List ( Filterable Excel file)

***The chart below goes over information regarding the most commonly used chemical hazards in animals,
but does not include all chemicals used at the University of Florida.

Chemical NameOther names usedCHP Needed for Lab Use?Include as a Toxic Agent in IACUC?ACS SOP Needed for handling CagesHazards
Bromodeoxyuridine5-bromo-2’-deoxyuridine, BrdUYYYUnused material should be picked up by EHS; contaminated bedding & carcasses should be incinerated. Confirmed teratogen, human mutagen, suspected teratogen/ reproductive toxin, strong toxin/sensitizing agent.
Carbon Tetrachloride CCl4YYYToxic by inhalation, ingestion, or skin abosorbtion. Carcinogen
CisplatinDichlotoplatinum Diammoniate; Cis-DiaminedichloroplatinumYYYSuspected human carcinogen, confirmed human mutagen, possible teratogen/reproductive toxin, acute toxin (LD50 rat oral 28.5 mg/kg)- extremely dangerous by all exposure routes.
Complete Freund’s Adjuvant CFA, Freund's Complete Adjuvant (FCA)YYYMay cause skin reactions, headaches, vomiting; return unused portion to lab for disposal through EH&S Hazardous Waste
CyclophosphamideCPH, CB-4564, Mitoxan, Clafen, Cytoxan, B518, Genoxal, Endoxan, Sendoxan, NSC 26271, Cyclophosphan eYYYConfirmed human carcinogen, teratogen, mutagen, embryotoxin, IARC group 1, NTP "known" human carcinogen, OSHA/NIOSH hazardous drug (antineoplastic agent).
DimethylsulfoxideDMSOYNNAvoid contact with DMSO solutions containing toxic materials or materials with unknown toxicological properties. Dimethyl sulfoxide is readily absorbed through skin and may carry such materials into the body. Use extreme caution and wear appropriate PPE.
DoxorubicinAdriamycin, 14-hydroxy daunomycin, DX, DXR, 5,12-napthacenedione, NCI-CO1514, NSC-123127YYYConfirmed human carcinogen and mutagen, suspected teratogen and reproductive toxin. Refer to MSDSs/Additional links for additional resources.
EthynyldeoxyuridineEdU, 5-Ethynyl-2′-deoxyuridine YYYReproductive toxin and potential mutagen
Evans Blue DyeYYNPossible carcinogenic properties, extensive animal test data indicating mutagenic, teratogenic, and reproductive toxin properties.
Formaldehyde/ formalin/paraformaldehydeYYNCarcinogen; irreversible damage to eyes; heritable genetic damage
GemcitabineYYYPossible mutagenic/reproductive toxin properties.
GlutaraldehydeCidexYYNtoxic by inhalation; causes burns; very toxic to aquatic organisms
LipopolysaccharideLPSYYNMay cause allergic skin reaction; avoid contact with eyes. In case of spill or leak, absorb/contain solution with inert materials. Prevent runoff from entering waterways or sewers as it may cause long-term adverse effects in the aquatic environment)
NicotineNicotine free-base, Black leaf, Nicotine hemisulfate 40% aqueous solution, Nicotine sulfate, dl-tetrahydronicotyrine, N'-nitrosonornicotine, Nicotine 1'-nitroso-1'-demethyl, (-)-nicotine, l-nicotine, 1-methyl-2-(3-pyridyl) pyrrolidine; "novel" nicotinic agentsYYNEPA-regulated hazardous waste; positive evidence of human fetal risk at high doses; 40–60 mg (0.5-1.0 mg/kg) can be a lethal dosage for adult humans; very hazardous in case of skin contact (permeator), of ingestion
PaclitaxelTaxol, Taxol AYYYMutagen, possible reproductive toxin
Pancuronium bromide Pancronium, PavulonYYNPossible mutagen, Ames test: mutagenic properties. Potent (subacute) toxin.
PFA/AcrylamideYYNtoxic if swallowed, carcinogen, mutagen, neurotoxin
Pilocarpine hydrochloride(3S,4R)-4,5-Dihydro-3-ethyl-4-(1-methyl-1H-imidazol-5-ylmethyl)-2(3H)-furanone hydrochloride, almocarpine, MI-Pilo, Pilocar, Pilocel, Pilocarpine hydrochloride.YYNStrong (subacute toxin) which can be fatal via inhalation, ingestion, or skin exposure, with additional potential for teratogenic and reproductive toxin effects. Seizure-inducing agent, handle with extreme care.
RapamycinAY 22989, NSC 226080, SirolimusYYYIrritant, possible mutagen, possible immune system depression, possible mutagen (animal data only).
Reproductive hormones/effectors (synthetic/natural)Mifepristone (RU-486), Lutalyse (PGF-2alpha), PGE1, estrogen, progesterone, etc. YYYPotential reproductive toxins and niche precautions (e.g. pregnant woment, men or women of childbearing age).
StreptozotocinSTZYYYHuman carcinogen, mutagen, and teratogen
TamoxifenTamoxifen citrate, novadex, tamofen, nolvadexYYYmay cause reproductive and fetal effects; potential cancer hazard
Temozolomide (TMZ)TMZ, Temodar, Temodal, NSC-362856, 3,4-dihydro-3-methyl-4-oxoimidazoleYYYCytotoxic, mutagenic, reproductive hazard, carcinogen, unused material should be picked up by EHS; contaminated bedding & carcasses should be incinerated
Tricaine MethanosulfonateMS-222, TricaineYYNirritant; do not discard into natural environment – dispose as hazardous waste
UrethaneEthyl Urethane, Ethyl CarbamateYYNCarcinogen, Mutagen, Suspected teratogen, and Reproductive toxin.