Animal Research Health & Safety
EH&S continuously works with the IACUC, IBC, and Animal Care Services to ensure the safety of staff working in animal research. During the IACUC review process, it is EH&S’ responsibility to identify any potential risks to staff safety. EH&S concerns are documented within the investigator’s IACUC protocol.
EH&S Tips for Conducting Animal Research
During the IACUC review process, EH&S will review the IACUC protocol for the following components, where applicable:
- Up to date Gator TRACS LATCH roster, complete/ accurate assessment, and personnel training
- Current and accurate DBPR and DEA permits (New PIs can start this process, but may require an approved IACUC protocol to complete the process)
- Source of transgenic animals- * Tg rodents (Rattus/Mus only) created at UF and non-rodent (Rattus/Mus only) Tg animals require registration through a Biohazard Project Registration
- Housing and procedure locations are appropriate for specified hazards (SOPs for transport and imaging if necessary- EH&S can provide templates)
- Caging options are appropriate for specified hazards
- Hazardous/ toxic chemicals, novel compounds of unknown toxicity, and nanoparticles
- *Biohazard Project Registrations for all agents that require registration.
- *Radiation Control Committee Projects/ approval for all radioisotope and irradiator use
- *Handling of contaminated animals and waste disposal procedures outlined through SOPs or text (EH&S can provide templates)
* Will HOLD final review of your protocol if these are not complete/ approved.
For questions, please email firstname.lastname@example.org.
- The UF IACUC verifies that all personnel listed on new and continuing animal use protocols are included in the Animal Contact Program, a medical monitoring program. Access to Animal Care Services managed facilities or vivaria also requires program participation.
- Complete the Risk Assessment for Animal Contact form prior to initial work, and at least every three years, or when new species are used in your research.
- - List all types of animal contact, current and anticipated.
- Track your medical clearance for animal contact online in myUFL>My Self Service>My Personal Information>UF Health Assessment
- For questions about the form, please contact Julie Ramsey at (352)392-1591.
- For medical questions, please call the OCCMED Clinic at (352) 294-5700.
- Upload your Chemicals in Animals SOP(s) into to your Laboratory Assessment Training, Chemical Hygiene plan (LATCH), in Gator TRACS.
- - Visit the EH&S website for instructions and login information
- For novel compounds, the following information should be addressed within the LATCH SOP:
- -Description of the parent, or closely related compound(s).
- -Current toxicity and pharmacokinetic data, if available.
For questions, please email: ARS@ehs.ufl.edu
All research projects involving biohazards (pathogens, recombinant/synthetic nucleic acids, and biotoxins with an LD50 ≤100 µg/kg body weight or that are controlled for export) are registered through the EHS Biosafety Office.
- For federal compliance, a subset will be forwarded to UF’s Institutional Biosafety Committee (IBC) for review and approval.
- -The IBC meets monthly; their meeting schedule and submission deadlines are on their website under schedule.
- The Biosafety Office sends out annual project review/update requests, although biohazard registrations may be amended at any time.
- See the flow chart on the use of biological materials in animals and subsequent IACUC reporting and approval.
The IBC revised its guidelines for the use of primary human cells and tissues and animals. Research animals injected, or engrafted, with primary human cells or tissues will be housed at Animal Biosafety Level 2 (ABSL-2) unless the cells/tissues have been properly screened using the IDEXX BioResearch h-IMPACT 1 testing panel.
For questions, please email: ARS@ehs.ufl.edu.
- A Field Safety Plan must be in place before work starts. Please use the Wildlife Research Safety Plan template.
- The IACUC protocol, Section 22.2.5, will outline precautions necessary for staff to minimize exposure to zoonotic diseases from wildlife.
- The following resources may be useful for Section 22.2.5:
For questions, please email: ARS@ehs.ufl.edu
Federal and State regulations apply. The EHS Laboratory Safety office maintains update-to-date copies of all Investigator’s DEA licenses and State of Florida DPBR Exemptions. Please forward current/ annual updates by sending them to Laboratory Safety.
- Please review the Waste Anesthetic Gas Fact Sheet and address the hazard where prompted in section 2.2 of your IACUC protocol.
- A State of Florida DPBR Exemption letter is required for medical grade gases and pharmaceuticals. More information can be found on the Lab Safety page concerning DEA procedures.
For questions please email: ARS@ehs.ufl.edu