Bioagent Export Control List

This list is subject to change, last updated May 2010.

Per Export Administrations Regulations (EAR) database http://www.access.gpo.gov/bis/ear/pdf/ccl1.pdf, a license will be required to export the following bioagents. Other export controls may apply for possession & use in the US. See http://rgp.ufl.edu/research/export_control/index.html for more information.

While many of these items are select agents, those preceded by an asterisk are not, but still require an export permit.

Human and Animal Pathogens

ITAR Controlled Items

Human and Animal Pathogens (1C351 & 1C360)

Viruses, as follows:
1)     Central European tick-borne encephalitis viruses, as follows:
        a) Absettarov
        b) Hanzalova
        c) Hypr
        d) Kumlinge
2)     Cercopithecine herpesvirus 1 (Herpes B virus)
3)     *Chikungunya virus
4)     Congo-Crimean haemorrhagic fever virus (a.k.a. Crimean-Congo haemorrhagic fever virus)
5)     *Dengue fever virus
6)     Eastern equine encephalitis virus
7)     Ebola virus
8)     *Hantaan virus
9)     Hendra virus (Equine morbillivirus)
10) 1918 pandemic influenza virus - reconstructed replication competent forms containing any portion of the coding regions of all eight gene segments
11) Japanese encephalitis virus
12) Junin virus
13) Kyasanur Forest virus
14) Lassa fever virus
15) *Louping ill virus
16) *Lymphocytic choriomeningitis virus
17) Machupo virus
18) Marburg virus
19) Monkey pox virus
20) *Murray Valley encephalitis virus
21) Nipah virus
22) Omsk haemorrhagic fever virus
23) *Oropouche virus
24) *Powassan virus
25) *Pulmonary & renal syndrome-haemorrhagic fever viruses (Seoul, Dobrava, Puumala, Sin Nombre)
26) Rift Valley fever virus
27) *Rocio virus
28) South American haemorrhagic fever (Sabia, Flexal, Guanarito)
29) *St. Louis encephalitis virus
30) Tick-borne encephalitis virus (Russian Spring-Summer encephalitis virus)
31) Variola virus
32) Venezuelan equine encephalitis virus
33) *Western equine encephalitis virus
34) *Yellow fever virus.

Bacteria & Rickettsiae, as follows:
1)     Bacillus anthracis
2)     *Bartonella quintana (Rochalimea quintana, Rickettsia quintana)
3)     Brucella abortus
4)     Brucella melitensis
5)     Brucella suis
6)     Burkholderia mallei (Pseudomonas mallei)
7)     Burkholderia pseudomallei (Pseudomonas pseudomallei)
8)     *Chlamydia psittaci
9)     Clostridium botulinum
10) *Clostridium perfringens, epsilon toxin producing types
11) Coxiella burnetii
12) *Enterohaemorrhagic Escherichia coli, serotype O157 and other verotoxin producing serotypes
13) Francisella tularensis
14) Rickettsia prowasecki (a.k.a. Rickettsia prowazekii)
15) Rickettsia rickettsii
16) *Salmonella typhi
17) *Shigella dysenteriae
18) *Vibrio cholerae
19) Yersinia pestis.

Fungi, as follows:
1)   Coccidioides immitis
2)   Coccidioides posadasii

Toxins and "subunits" thereof (1C351 & 1C360)

1)     Abrin
2)     *Aflatoxins
3)     Botulinum toxins
4)     *Cholera toxin
5)     Clostridium perfringens toxins
6)     Conotoxin
7)     Diacetoxyscirpenol toxin
8)     *HT-2 toxin
9)     *Microcystin (Cyanginosin)
10)   *Modeccin toxin
11) Ricin in the form of
        a) Ricinus Communis Agglutinin_II (RCA_II), also known as ricin D or Ricinus Communis Lectin_III (RCL_III) and
        b) Ricinus Communis Lectin_IV(RCL_IV), also known as ricin E.
12) Saxitoxin for saxitoxin identified by C.A.S. #35523-89-8.
13) Shiga toxin
14) Staphylococcus aureus toxins
15) T-2 toxin
16) Tetrodotoxin
17) Verotoxin and other Shiga-like ribosome inactivating proteins
18) *Viscum Album Lectin 1 (Viscumin)
19) *Volkensin toxin.

Animal Pathogens (1C352 & 1C360)

Viruses, as follows:
1)     African horse sickness virus
2)     African swine fever virus
3)     Akabane virus
4)     Avian influenza (AI) viruses that:
        a) have an intravenous pathogenicity index (IVPI) in 6-week old chickens greater than 1.2 or
        b) cause at least 75% mortality in 4- to 8-week old chickens infected intravenously.

Note: AI viruses of the H5 or H7 subtype that do not have either of the characteristics described above should be sequenced to determine whether multiple basic amino acids are present at the cleavage site of the haemagglutinin molecule (HA0). If the amino acid motif is similar to that observed for other HPAI isolates, then the isolate being tested should be considered as HPAI and the virus is export controlled.

5)     Bluetongue virus
6)     Bovine spongiform encephalopathy agent
7)     Camel pox virus
8)     Foot and mouth disease virus
9)     Goat pox virus
10) Lumpy skin disease virus
11) *Lyssa virus
12) Malignant catarrhal fever virus
13) Menangle virus
14) Newcastle disease virus
15) Peste des petits ruminants virus
16) Porcine enterovirus type 9 (swine vesicular disease virus)
17) *Porcine herpes virus (Aujeszky's disease)
18) Rinderpest virus
19) Sheep pox virus
20) Swine fever virus (Hog cholera virus)
21) *Teschen disease virus
22) ^ΔVesicular stomatitis virus.

Mycoplasma, as follows:
1)   Mycoplasma capricolum
2)   Mycoplasma capricolum subspecies capripneumoniae (“strain F38”)
3)   Mycoplasma mycoides, as follows:
        a) Mycoplasma mycoides subspecies mycoides SC (small colony) (a.k.a. contagious bovine pleuropneumonia)
        b) Mycoplasma mycoides capri

Rickettsiae, as follows:
1)   Erhlichia ruminantium (a.k.a.Cowdria ruminantium).

^ΔExotic strains of Vesicular stomatitis virus are select agents

Plant Pathogens (1C354 & 1C360)

Viruses, as follows:
1)   *Potato Andean latent tymovirus
2)   *Potato spindle tuber viroid.

Bacteria, as follows:
1)   *Clavibacter michiganensis subspecies sepedonicus (syn. Corynebacterium michiganensis subspecies sepedonicum or Corynebacterium sepedonicum)
2)   Ralstonia solanacearum Races 2 and 3 (syn. Pseudomonas solanacearum Races 2 and 3 or Burkholderia solanacearum Races 2 and 3)
3)   Rathayibacter toxicus
4)   *Xanthomonas albilineans
5)   *Xanthomonas campestris pv. citri including strains referred to as Xanthomonas campestris pv. citri types A,B,C,D,E or otherwise classified as Xanthomonas citri, Xanthomonas campestris pv. aurantifolia or Xanthomonas campestris pv. citrumelo
6)   Xanthomonas oryzae pv. oryzae (syn.Pseudomonas campestris pv. oryzae)
7)   Xylella fastidiosa pv. citrus variegated chlorosis (CVC).

Fungi, as follows:
1)     *Cochliobolus miyabeanus (Helminthosporium oryzae)
2)     *Colletotrichum coffeanum var. virulans (Colletotrichum kahawae)
3)     *Magnaporthe grisea (pyricularia grisea/pyricularia oryzae)
4)     *Microcyclus ulei (syn. Dothidella ulei)
5)     Peronosclerospora philippinensis (a.k.a. Peronosclerospora sachhari)
6)     Phoma glycinicola (formerly Pyrenochaeta glycines)
7)     *Puccinia graminis (syn. Puccinia graminis f. sp. tritici)
8)     *Puccinia striiformis (syn. Puccinia glumarum)
9)     Sclerophthora rayssiae var. zeae
10)   Synchytrium endobioticum

Genetic elements and genetically-modified organisms (1C353)

Genetic elements, as follows:
1)   Genetic elements that contain nucleic acid sequences associated with the pathogenicity of microorganisms listed above (controlled by 1C351.a to .c, 1C352, 1C354, or 1C360)
2)   Genetic elements that contain nucleic acid sequences coding for any of the "toxins" (controlled by 1C351.d) or "sub-units of toxins" listed above.

Genetically modified organisms, as follows:
1)   Genetically modified organisms that contain nucleic acid sequences associated with the pathogenicity of microorganisms listed above (controlled by 1C351.a to .c, 1C352, 1C354, or 1C360)
2)   Genetically modified organisms that contain nucleic acid sequences coding for any of the "toxins" (controlled by 1C351.d) or "sub-units of toxins" listed above.

Notes:
1) "Genetic elements" include, inter alia, chromosomes, genomes, plasmids, transposons, and vectors, whether genetically modified or unmodified.
2) This rule does not control nucleic acid sequences associated with the pathogenicity of enterohaemorrhagic Escherichia coli, serotype O157 and other verotoxin producing strains, except those nucleic acid sequences that contain coding for the verotoxin or its sub-units.
3) "Nucleic acid sequences associated with pathogenicity” (controlled by 1C351.a to .c, 1C352, 1C354, or 1C360) means any sequence specific to the relevant controlled microorganism that:
a. In itself or through its transcribed or translated products represents a significant hazard to human, animal or plant health or
b. Is known to enhance the ability of a microorganism listed above (controlled by 1C351.a to .c, 1C352, 1C354, or 1C360), or any other organism into which it may be inserted or otherwise integrated, to cause serious harm to human, animal or plant health.

International Traffic in Arms Regulations (ITAR) Category XIV: Toxicological Agents Including Chemical, Biological Agents, and Associated Equipment

MULTIPLE Export Controls, INCLUDING a License will be required to use or possess the following. See http://pmddtc.state.gov/regulations_laws/documents/consolidated_itar/2009/Part_121.pdf#page=22

“(b) Biological agents and biologically derived substances specifically developed, configured, adapted, or modified for the purpose of increasing their capability to produce casualties in humans or livestock, degrade equipment or damage crops.”

“(f) Equipment and its components, parts, accessories, and attachments specifically designed or modified for military operations and compatibility with military equipment. . . ." Note that equipment used with biological materials may be included under this category.